Mitochondria, along with their functions and the reactive oxygen species (ROS) they produce, have been repeatedly associated with various processes and chronic diseases across numerous studies.
The effects of lifespan and healthspan vary among different interventions, indicating distinct roles for specific mitochondrial reactive oxygen species and their influence on typical ageing. Consistent results in myocardial protection across multiple interventions underscore the importance of examining the effects of cardiac ageing on healthspan.
Reference: Wanagat J, Dai DF, Rabinovitch P. Mitochondrial oxidative stress and mammalian healthspan. Mech Ageing Dev. 2010 Jul-Aug;131(7-8):527-35.